Epimerization of Cyclic Alanyl-Alanine in Basic Solutions
نویسندگان
چکیده
منابع مشابه
Complexation of acetyl-D-alanyl-D-alanine by antibiotic A35512B.
Antibiotic A3 5512B1.2) is a member of the glycopeptide family of antibiotics; complete structures have been reported for two members of this group, vancomycin3' and ristocetin A4' a) . Both vancomycin and ristocetin have been shown to form complexes with mucopeptides containing the terminal dipeptide D-alanyl-D-alaninee) ; this interaction within the bacterial cell inhibits crosslinking of the...
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The steady state kinetic mechanism, molecular isotope exchange and the positional isotope exchange (PIX) reactions of D-alanyl-D-alanine ligase from Salmonella typhimurium have been studied. The kinetic mechanism has been determined to be ordered Ter-Ter from initial velocity and product inhibition experiments. The first substrate to bind is ATP followed by the addition of 2 mol of D-alanine. P...
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متن کاملInsensitivity of bacteria to proposed antimetabolites of D-alanyl-D-alanine.
alpha-Aminoisobutyryl-d-alanine, d-alanyl-alpha-aminoisobutyric acid, and alpha-amino-isobutyryl-alpha-aminoisobutyric acid, proposed as antimetabolites of d-alanyl-d-alanine in bacterial cell wall synthesis, failed to inhibit bacterial growth.
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ژورنال
عنوان ژورنال: Oriental Journal of Chemistry
سال: 2014
ISSN: 0970-020X,2231-5039
DOI: 10.13005/ojc/300103